Bleomycin sulfate( Blenoxane )

Catalog No. M16501 CAS No. 9041-93-4

COA

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Product Name

Bleomycin sulfate
Note

Research use only, not for human use.
Brief Description

An anticancer agent that acts by induction of DNA strand breaks; also inhibits incorporation of thymidine into DNA strands.
Description

An anticancer agent that acts by induction of DNA strand breaks; also inhibits incorporation of thymidine into DNA strands; a hybrid peptide-polyketide natural product.Pancreatic Cancer Phase 3 Clinical.
In Vitro

——
In Vivo

Animal Model:Male?Fischer 344 rats, 8-10 week old, weighing 150-250?g Dosage:3.5-4 mg/kg Administration:Intra-tracheal Result:Body weights decreased by day 4 then increased by Day 7 through the end of the study.
Synonyms

Blenoxane
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNASynthesis
Research Area

Cancer
Indication

Pancreatic Cancer

CAS Number

9041-93-4
Formula Weight

1512.622
Molecular Formula

C55H85N17O25S4
Purity

>98% (HPLC)
Solubility

DMSO: < 11.2 mg/mL
SMILES

CC(O)C(NC(=O)C(C)C(O)C(C)NC(=O)C(NC(=O)C1=C(C)C(N)=NC(=N1)C(CC(N)=O)NCC(N)C(N)=O)C(OC1OC(CO)C(O)C(O)C1OC1OC(CO)C(O)C(OC(N)=O)C1O)C1=CN=CN1)C(=O)NCCC1=NC(=CS1)C1=NC(=CS1)C(=O)NCCC[S+](C)C
Chemical Name

Bleomycin, sulfate (salt)